The Effect of Triptolide Combined With Crocin on Arthritis in Mice: From Side Effect Attenuation to Therapy

• Main Authors: Min Yan (Author), Yinyin Yan (Author), Zhenqiang Zhang (Author), Guoqiang Wang (Author), Wenbo Shi (Author), Mengyuan Jiang (Author), Junwei Zhao (Author), Xiangxiang Wu (Author), Huahui Zeng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clinical use of triptolide (TP) is restricted due to severe toxicity. This study assessed the protective effect of crocin (CR) as a natural antioxidant against TP-induced toxicity in bovine collagen type II-induced arthritis (CIA) in mice. The mice in the CIA model group showed macroscopic signs of...