Dengue virus activates membrane TRAIL relocalization and IFN-α production by human plasmacytoid dendritic cells in vitro and in vivo.

• Main Authors: Mariana Gandini (Author), Christophe Gras (Author), Elzinandes Leal Azeredo (Author), Luzia Maria de Oliveira Pinto (Author), Nikaïa Smith (Author), Philippe Despres (Author), Rivaldo Venâncio da Cunha (Author), Luiz José de Souza (Author), Claire Fernandes Kubelka (Author), Jean-Philippe Herbeuval (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Dengue displays a broad spectrum of clinical manifestations that may vary from asymptomatic to severe and even fatal features. Plasma leakage/hemorrhages can be caused by a cytokine storm induced by monocytes and dendritic cells during dengue virus (DENV) replication. Plasmacytoid dendri...