Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR

Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR

Background: Oleanolic acid (OA) and its isomer ursolic acid (UA) have recently emerged as research foci based on their biologic activities. We previously demonstrated that UA can inhibit the activities of UGT1A3 and UGT1A4, and OA inhibits UGT1A3 activity in liver microsomes. However, whether OA and...

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Main Authors: Na Yao (Author), Caiwen Zeng (Author), Tao Zhan (Author), Fang He (Author), Mingyi Liu (Author), Fanglan Liu (Author), Hong Zhang (Author), Yuqing Xiong (Author), Chunhua Xia (Author)
Format: Book
Published: Frontiers Media S.A., 2019-09-01T00:00:00Z.
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