Development of a UHPLC-MS/MS method for the quantification of ilaprazole enantiomers in rat plasma and its pharmacokinetic application

• Autori principali: Fengting Ou (Autore), Ying Zhou (Autore), Jinxiu Lei (Autore), Su Zeng (Autore), Fuhai Wu (Autore), Ning Zhang (Autore), Lushan Yu (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2020-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

In Korea and China, ilaprazole is a widely used proton pump inhibitor in the treatment of gastric ulcers. In this study, a specific and sensitive LC-MS/MS method has been developed and validated for the quantification of ilaprazole enantiomers in the rat plasma, using R-lansoprazole as the internal...