(L)-Monomethyl Tyrosine (Mmt): New Synthetic Strategy via Bulky 'Forced-Traceless' Regioselective Pd-Catalyzed C(sp²)-H Activation

• Main Authors: Davide Illuminati (Author), Claudio Trapella (Author), Vinicio Zanirato (Author), Remo Guerrini (Author), Valentina Albanese (Author), Chiara Sturaro (Author), Simona Stragapede (Author), Davide Malfacini (Author), Greta Compagnin (Author), Martina Catani (Author), Anna Fantinati (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The enormous influence in terms of bioactivity, affinity, and selectivity represented by the replacement of (L)-2,6-dimethyl tyrosine (Dmt) instead of Phenylalanine (Phe) into Nociceptin/orphanin (N/OFQ) neuropeptide analogues has been well documented in the literature. More recently, the non-natura...