HIV-1 RT-Associated RNase H review
HIV-RT is an essential enzyme for HIV replication it comprises two associated functions: RNA- and DNA-dependent DNA polymerase (RDDP & DDDP) and ribonuclease H (RNase H). The RNase H is function to cleave RNA strand in RNA/DNA hybrid intermediate in the reverse transcription process. Currently,...
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| Format: | Book |
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Ain Shams University,
2018-06-01T00:00:00Z.
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| 001 | doaj_6b39df7a3c2a4f609b78894b4f8b4f93 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Madonna M. A. Mitry |e author |
| 700 | 1 | 0 | |a Nermin S. Abdou |e author |
| 700 | 1 | 0 | |a Rabah A. T. Serya |e author |
| 245 | 0 | 0 | |a HIV-1 RT-Associated RNase H review |
| 260 | |b Ain Shams University, |c 2018-06-01T00:00:00Z. | ||
| 500 | |a https://dx.doi.org/10.21608/aps.2018.18731 | ||
| 500 | |a 2356-8380 | ||
| 500 | |a 2356-8399 | ||
| 520 | |a HIV-RT is an essential enzyme for HIV replication it comprises two associated functions: RNA- and DNA-dependent DNA polymerase (RDDP & DDDP) and ribonuclease H (RNase H). The RNase H is function to cleave RNA strand in RNA/DNA hybrid intermediate in the reverse transcription process. Currently, successful inhibitors target the polymerase function of HIV-RT. RNase H evolves to be a promising target for anti-HIV drug research. This review describes the compounds reported as HIV-1 RNase H inhibitors. | ||
| 546 | |a EN | ||
| 690 | |a HIV-1 | ||
| 690 | |a ribonuclease H | ||
| 690 | |a reverse transcriptase | ||
| 690 | |a tropolone | ||
| 690 | |a Hydrazone | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Archives of Pharmaceutical Sciences Ain Shams University, Vol 2, Iss 1, Pp 22-30 (2018) | |
| 787 | 0 | |n https://aps.journals.ekb.eg/article_18731.html | |
| 787 | 0 | |n https://doaj.org/toc/2356-8380 | |
| 787 | 0 | |n https://doaj.org/toc/2356-8399 | |
| 856 | 4 | 1 | |u https://doaj.org/article/6b39df7a3c2a4f609b78894b4f8b4f93 |z Connect to this object online. |