Applications of High-Throughput Sequencing for In Vitro Selection and Characterization of Aptamers
Aptamers are identified through an iterative process of evolutionary selection starting from a random pool containing billions of sequences. Simultaneously to the amplification of high-affinity candidates, the diversity in the pool is exponentially reduced after several rounds of in vitro selection....
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MDPI AG,
2016-12-01T00:00:00Z.
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