Astragalus saponins and its main constituents ameliorate ductular reaction and liver fibrosis in a mouse model of DDC-induced cholestatic liver disease

• Main Authors: Linzhang Zhang (Author), Yonghong Hu (Author), Shenglan Qi (Author), Congcong Zhang (Author), Qun Zhou (Author), Dingqi Zhang (Author), Yongping Mu (Author), Hua Zhang (Author), Gaofeng Chen (Author), Ping Liu (Author), Jiamei Chen (Author), Wei Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cholestatic liver disease (CLD) is a chronic liver disease characterized by ductular reaction, inflammation and fibrosis. As there are no effective chemical or biological drugs now, majority of CLD patients eventually require liver transplantation. Astragali radix (AR) is commonly used in the clinic...