Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity

• Main Authors: Peijian Zhang (Author), Erlinda The (Author), Zichao Luo (Author), Yufeng Zhai (Author), Qingzhou Yao (Author), Lihua Ao (Author), David A. Fullerton (Author), Dingli Xu (Author), Xianzhong Meng (Author)
• Format: Book
• Published: BMC, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Calcific aortic valve disease (CAVD) is the most prevalent heart valve disorder in the elderly. Valvular fibrocalcification is a characteristic pathological change. In diseased valves, monocyte accumulation is evident, and aortic valve interstitial cells (AVICs) display greater f...