Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors

• Main Authors: Yongfang Yao (Author), Tao Huang (Author), Yuyang Wang (Author), Longfei Wang (Author), Siqi Feng (Author), Weyland Cheng (Author), Longhua Yang (Author), Yongtao Duan (Author)
• פורמט: ספר
• יצא לאור: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

The screened compound DYT-1 from our in-house library was taken as a lead (inhibiting tubulin polymerisation: IC50=25.6 µM, anti-angiogenesis in Zebrafish: IC50=38.4 µM, anti-proliferation against K562 and Jurkat: IC50=6.2 and 7.9 µM, respectively). Further investigation of medicinal chemistry condi...