Fluidised bed granulation of two APIs: QbD approach and development of a NIR in-line monitoring method

• Main Authors: Alexandru Gavan (Author), Sonia Iurian (Author), Tibor Casian (Author), Alina Porfire (Author), Sebastian Porav (Author), Ioana Voina (Author), Alexandru Oprea (Author), Ioan Tomuta (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The study focused on the fluid-bed granulation process of a product with two active pharmaceutical ingredients, intended for coated tablets preparation and further transfer to industrial scale. The work aimed to prove that an accurate control of the critical granulation parameters can level the inpu...