Decreasing CB1 receptor signaling in Kupffer cells improves insulin sensitivity in obese mice

• Main Authors: Tony Jourdan (Author), Sarah M. Nicoloro (Author), Zhou Zhou (Author), Yuefei Shen (Author), Jie Liu (Author), Nathan J. Coffey (Author), Resat Cinar (Author), Grzegorz Godlewski (Author), Bin Gao (Author), Myriam Aouadi (Author), Michael P. Czech (Author), George Kunos (Author)
• Format: Book
• Published: Elsevier, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Obesity-induced accumulation of ectopic fat in the liver is thought to contribute to the development of insulin resistance, and increased activity of hepatic CB1R has been shown to promote both processes. However, lipid accumulation in liver can be experimentally dissociated from insulin...