Targeting Beclin1 as an Adjunctive Therapy against HIV Using Mannosylated Polyethylenimine Nanoparticles

• Hoofdauteurs: Myosotys Rodriguez (Auteur), Yemmy Soler (Auteur), Mohan Kumar Muthu Karuppan (Auteur), Yuling Zhao (Auteur), Elena V. Batrakova (Auteur), Nazira El-Hage (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2021-02-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Using nanoparticle-based RNA interference (RNAi), we have previously shown that silencing the host autophagic protein, Beclin1, in HIV-infected human microglia and astrocytes restricts HIV replication and its viral-associated inflammatory responses. Here, we confirmed the efficacy of Beclin1 small i...