Gut Microbiota-Mediated Pharmacokinetic Drug-Drug Interactions between Mycophenolic Acid and Trimethoprim-Sulfamethoxazole in Humans

• Main Authors: Nahathai Dukaew (Author), Patcharawadee Thongkumkoon (Author), Nutnicha Sirikaew (Author), Sivamoke Dissook (Author), Wannachai Sakuludomkan (Author), Siripong Tongjai (Author), Parameth Thiennimitr (Author), Mingkwan Na Takuathung (Author), Juthipong Benjanuwattra (Author), Prachya Kongthaweelert (Author), Nut Koonrungsesomboon (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mycophenolic acid (MPA) and trimethoprim-sulfamethoxazole (TMP-SMX) are commonly prescribed together in certain groups of patients, including solid organ transplant recipients. However, little is known about the pharmacokinetic drug-drug interactions (DDIs) between these two medications. Therefore,...