Platelet gene therapy induces robust immune tolerance even in a primed model via peripheral clonal deletion of antigen-specific T cells

• Autori principali: Jing Li (Autore), Juan Chen (Autore), Jocelyn A. Schroeder (Autore), Jianda Hu (Autore), Calvin B. Williams (Autore), Qizhen Shi (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2021-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

While platelet-specific gene therapy is effective in inducing immune tolerance to a targeted protein, how the reactivity of pre-existing immunity affects the efficacy, and whether CD8 T cells were involved in tolerization, is unclear. In this study, ovalbumin (OVA) was used as a surrogate protein. P...