MyD88 activation in cardiomyocytes contributes to the heart immune response to acute Trypanosoma cruzi infection with no effect on local parasite control.

• Main Authors: Danni Yohani Santana (Author), Rafael Moysés Salgado (Author), Marina Fevereiro (Author), Rogério Silva do Nascimento (Author), Raissa Fonseca (Author), Niels Olsen Saraiva Câmara (Author), Sabrina Epiphanio (Author), Cláudio Romero Farias Marinho (Author), Maria Luiza Barreto-Chaves (Author), Maria Regina D' Império-Lima (Author), José M Álvarez (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cardiomyopathy is the most serious consequence of Chagas disease, a neglected human disorder caused by Trypanosoma cruzi infection. Because T. cruzi parasites invade cardiomyocytes, we sought to investigate whether these cells recognize the parasite in vivo by receptors signaling through the MyD88 a...