α1-adrenoceptor ligands inhibit chemokine receptor heteromerization partners of α1B/D-adrenoceptors via interference with heteromer formation

• Главные авторы: Xianlong Gao (Автор), Garrett A. Enten (Автор), Michelle Y. McGee (Автор), McWayne Weche (Автор), Matthias Majetschak (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2023-04-01T00:00:00Z.
• Предметы: article
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We reported previously that α1-adrenoceptor (α1-AR) ligands inhibit chemokine receptor (CR) heteromerization partners of α1B/D-AR. The underlying mechanisms are unknown and in vivo evidence for such effects is missing. Utilizing CCR2 and α1B-AR as prototypical partners, we observed in recombinant sy...