Tracking Dengue Virus Intra-host Genetic Diversity during Human-to-Mosquito Transmission.

• Main Authors: Shuzhen Sim (Author), Pauline P K Aw (Author), Andreas Wilm (Author), Garrett Teoh (Author), Kien Duong Thi Hue (Author), Nguyet Minh Nguyen (Author), Niranjan Nagarajan (Author), Cameron P Simmons (Author), Martin L Hibberd (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dengue virus (DENV) infection of an individual human or mosquito host produces a dynamic population of closely-related sequences. This intra-host genetic diversity is thought to offer an advantage for arboviruses to adapt as they cycle between two very different host species, but it remains poorly c...