An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels

• Main Authors: Yiguo Sun (Author), Xiaoling Tong (Author), Honghong Chen (Author), Tao Huang (Author), Qing Shao (Author), Weixiong Huang (Author), Dale W. Laird (Author), Donglin Bai (Author)
• Format: Book
• Published: The Company of Biologists, 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Connexin40 (Cx40)-containing gap-junction channels are expressed in the atrial myocardium and provide a low-resistance passage for rapid impulse propagation. A germline mutation in the GJA5 gene, which encodes Cx40, resulting in a truncated Cx40 (Q49X) was identified in a large Chinese family with l...