Therapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer

• Main Authors: Yun Wu (Author), Melissa Crawford (Author), Yicheng Mao (Author), Robert J Lee (Author), Ian C Davis (Author), Terry S Elton (Author), L James Lee (Author), Serge P Nana-Sinkam (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MicroRNA-29b (miR-29b) expression has been shown to be reduced in non-small-cell lung cancer (NSCLC) tissues. Here, we have identified the oncogene cyclin-dependent protein kinase 6 (CDK6) as a direct target of miR-29b in lung cancer. We hypothesized that in vivo restoration of miR-29b and thus targ...