Total body fluid is the factor that affects the pharmacokinetics of tolvaptan, and its efficacy, in acute worsening heart failure patients

• Main Authors: Takahiro Kato (Author), Yoko Yasuda (Author), Hitomi Okamoto (Author), Yuji Saito (Author), Yusuke Nakano (Author), Katsuhiko Matsuura (Author), Masafumi Oonishi (Author), Tetsuya Amano (Author)
• Format: Book
• Published: Wiley, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The optimal starting dose of tolvaptan to effectively improve fluid retention in patients with heart failure (HF) is unknown. This study explored the factors affecting the pharmacokinetics (PKs) and pharmacodynamics of tolvaptan in patients with decompensated HF. We prospectively enrolled p...