Peripheral administration of SB223412, a selective neurokinin-3 receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting on the gonadotropin-releasing hormone pulse generator in estrogen-treated ovariectomized female goats

• Main Authors: Takuya SASAKI (Author), Tomoya SONODA (Author), Ryoki TATEBAYASHI (Author), Yuri KITAGAWA (Author), Shinya OISHI (Author), Koki YAMAMOTO (Author), Nobutaka FUJII (Author), Naoko INOUE (Author), Yoshihisa UENOYAMA (Author), Hiroko TSUKAMURA (Author), Kei-ichiro MAEDA (Author), Fuko MATSUDA (Author), Yasuhiro MORITA (Author), Shuichi MATSUYAMA (Author), Satoshi OHKURA (Author)
• Format: Book
• Published: The Society for Reproduction and Development, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Accumulating evidence suggests that KNDy neurons located in the hypothalamic arcuate nucleus (ARC), which are reported to express kisspeptin, neurokinin B, and dynorphin A, are indispensable for the gonadotropin-releasing hormone (GnRH) pulse generation that results in rhythmic GnRH secretion. The a...