Interspecies Brain PBPK Modeling Platform to Predict Passive Transport through the Blood-Brain Barrier and Assess Target Site Disposition

• Main Authors: Parsshava Mehta (Author), Amira Soliman (Author), Leyanis Rodriguez-Vera (Author), Stephan Schmidt (Author), Paula Muniz (Author), Monica Rodriguez (Author), Marta Forcadell (Author), Emili Gonzalez-Perez (Author), Valvanera Vozmediano (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The high failure rate of central nervous system (CNS) drugs is partly associated with an insufficient understanding of target site exposure. Blood-brain barrier (BBB) permeability evaluation tools are needed to explore drugs' ability to access the CNS. An outstanding aspect of physiologically b...