Oral FXIIa inhibitor KV998086 suppresses FXIIa and single chain FXII mediated kallikrein kinin system activation

• Main Authors: Allen C. Clermont (Author), Nivetha Murugesan (Author), Hannah J. Edwards (Author), Daniel K. Lee (Author), Natasha P. Bayliss (Author), Edward J. Duckworth (Author), Stephen J. Pethen (Author), Sally L. Hampton (Author), David Gailani (Author), Edward P. Feener (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The kallikrein kinin system (KKS) is an established pharmacological target for the treatment and prevention of attacks in hereditary angioedema (HAE). Proteolytic activities of FXIIa and single-chain Factor XII (FXII) zymogen contribute to KKS activation and thereby may play roles in bot...