Tolerogenic Dendritic Cells Induced by BD750 Ameliorate Proinflammatory T cell Responses and Experimental Autoimmune Encephalitis in Mice

• 主要な著者: Yan Zhou (著者), Xiao Leng (著者), Hua Li (著者), Shuxia Yang (著者), Tai Yang (著者), Limei Li (著者), Ying Xiong (著者), Qiang Zou (著者), Yang Liu (著者), Yantang Wang (著者)
• フォーマット: 図書
• 出版事項: BMC, 2017-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract BD750, a novel JAK3/STAT5 inhibitor, can inhibit T cell proliferation. This study aims to evaluate whether BD750 can induce tolerogenic dendritic cells (tolDC) and their function in experimental autoimmune encephalitis (EAE) in mice. Following BD750 treatment, lipopolysaccharide (LPS)-induc...