Tolerogenic Dendritic Cells Induced by BD750 Ameliorate Proinflammatory T cell Responses and Experimental Autoimmune Encephalitis in Mice

• Main Authors: Yan Zhou (Author), Xiao Leng (Author), Hua Li (Author), Shuxia Yang (Author), Tai Yang (Author), Limei Li (Author), Ying Xiong (Author), Qiang Zou (Author), Yang Liu (Author), Yantang Wang (Author)
• Format: Book
• Published: BMC, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract BD750, a novel JAK3/STAT5 inhibitor, can inhibit T cell proliferation. This study aims to evaluate whether BD750 can induce tolerogenic dendritic cells (tolDC) and their function in experimental autoimmune encephalitis (EAE) in mice. Following BD750 treatment, lipopolysaccharide (LPS)-induc...