Protective Effects of Methotrexate against Proatherosclerotic Cytokines: A Review of the Evidence

• Main Authors: Arduino A. Mangoni (Author), Angelo Zinellu (Author), Salvatore Sotgia (Author), Ciriaco Carru (Author), Matteo Piga (Author), Gian Luca Erre (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is good epidemiological evidence that patients with autoimmune rheumatic disease states, particularly rheumatoid arthritis, have an increased risk of cardiovascular morbidity and mortality when compared to the general population. The presence of a chronic systemic proinflammatory state in this...