Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice

• Main Authors: Adam Denes (Author), Fiona Wilkinson (Author), Brian Bigger (Author), Michael Chu (Author), Nancy J. Rothwell (Author), Stuart M. Allan (Author)
• Format: Book
• Published: The Company of Biologists, 2013-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Interleukin-1 (IL-1) is a key regulator of inflammation and ischaemic brain injury, but the contribution of central and peripheral sources of IL-1 to brain injury is not well understood. Here we show that haematopoietic-derived IL-1 is a key driver of ischaemic brain injury. Wild type (WT) m...