Novel Population Pharmacokinetic Model for Linezolid in Critically Ill Patients and Evaluation of the Adequacy of the Current Dosing Recommendation

• Main Authors: Amaia Soraluce (Author), Helena Barrasa (Author), Eduardo Asín-Prieto (Author), Jose Ángel Sánchez-Izquierdo (Author), Javier Maynar (Author), Arantxazu Isla (Author), Alicia Rodríguez-Gascón (Author)
• Format: Book
• Published: MDPI AG, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antimicrobial treatment in critically ill patients remains challenging. The aim of this study was to develop a population pharmacokinetic model for linezolid in critically ill patients and to evaluate the adequacy of current dosing recommendation (600 mg/12 h). Forty inpatients were included, 23 of...