Targeting cancer homing into the lymph node with a novel anti-CCR7 therapeutic antibody: the paradigm of CLL

• Main Authors: Carlos Cuesta-Mateos (Author), Raquel Juárez-Sánchez (Author), Tamara Mateu-Albero (Author), Javier Loscertales (Author), Wim Mol (Author), Fernando Terrón (Author), Cecilia Muñoz-Calleja (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lymph node (LN) is a key tissue in the pathophysiology of mature blood cancers, especially for chronic lymphocytic leukemia (CLL). Within the multiple de-regulated pathways affecting CLL homeostasis, the CC-chemokine receptor 7 (CCR7) grants homing of CLL cells into the LN where protective environme...