A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure

• Main Authors: Keith S. K. Fong (Author), Robert B. Hufnagel (Author), Vedbar S. Khadka (Author), Michael J. Corley (Author), Alika K. Maunakea (Author), Ben Fogelgren (Author), Zubair M. Ahmed (Author), Scott Lozanoff (Author)
• Format: Book
• Published: The Company of Biologists, 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genetic variations affecting neural tube closure along the head result in malformations of the face and brain. Neural tube defects (NTDs) are among the most common birth defects in humans. We previously reported a mouse mutant called tuft that arose spontaneously in our wild-type 3H1 colony. Adult t...