Left-shifted Nav channels in injured bilayer: primary targets for neuroprotective Nav antagonists?
In sodium channel (Nav)-rich axon initial segments and nodes of Ranvier, mechanical, ischemic and inflammatory injuries render these voltage-gated channels dangerously leaky. Extrapolating from recombinant Nav1.6 behavior (Wang et al 2009 Am J Physiol 297:C823), we postulate that the structural degr...
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Frontiers Media S.A.,
2012-02-01T00:00:00Z.
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A1234.567 |
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