Left-shifted Nav channels in injured bilayer: primary targets for neuroprotective Nav antagonists?

In sodium channel (Nav)-rich axon initial segments and nodes of Ranvier, mechanical, ischemic and inflammatory injuries render these voltage-gated channels dangerously leaky. Extrapolating from recombinant Nav1.6 behavior (Wang et al 2009 Am J Physiol 297:C823), we postulate that the structural degr...

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Main Authors: Catherine E Morris (Author), Pierre Alexandre Boucher (Author), Bela eJoos (Author)
Format: Book
Published: Frontiers Media S.A., 2012-02-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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