Lipodystrophy and severe metabolic dysfunction in mice with adipose tissue-specific insulin receptor ablation

• Main Authors: Guifen Qiang (Author), Hyerim Whang Kong (Author), Shanshan Xu (Author), Hoai An Pham (Author), Sebastian D. Parlee (Author), Aaron A. Burr (Author), Victoria Gil (Author), Jingbo Pang (Author), Amy Hughes (Author), Xuejiang Gu (Author), Giamila Fantuzzi (Author), Ormond A. MacDougald (Author), Chong Wee Liew (Author)
• Format: Book
• Published: Elsevier, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Insulin signaling plays pivotal roles in the development and metabolism of many tissues and cell types. A previous study demonstrated that ablation of insulin receptor (IR) with aP2-Cre markedly reduced adipose tissues mass and protected mice from obesity. However, multiple studies have d...