Empagliflozin induces apoptotic-signaling pathway in embryonic vasculature: In vivo and in silico approaches via chick's yolk sac membrane model

• Main Authors: Saeedeh Mosallanejad (Author), Mehdi Mahmoodi (Author), Hadi Tavakkoli (Author), Ahmad Khosravi (Author), Ehsan Salarkia (Author), Alireza Keyhani (Author), Shahriar Dabiri (Author), Mohammad Hossein Gozashti (Author), Abbas Pardakhty (Author), Hadi Khodabandehloo (Author), Hossein Pourghadamyari (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present investigation was conducted to evaluate the vascular-toxicity of empagliflozin (EMP) in embryonic vasculature. Firstly, the vascular-toxicity of the drug as well as its interaction with apoptotic regulator proteins was predicted via in silico approach. In the next step, the apoptotic-sig...