Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia

• Main Authors: Xiaobao Zhang (Author), Fang Yan (Author), Jizheng Cui (Author), Yong Wu (Author), Hengfei Luan (Author), Miaomiao Yin (Author), Zhibin Zhao (Author), Jiying Feng (Author), Jinwei Zhang (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Microglia play an important role in mediating inflammatory processes in the central nervous system (CNS). Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor and could decrease neuropathology in Alzheimer's disease (AD). However, the detailed mechanism rema...