Reverse Remodeling in Human Heart Failure after Cardiac Resynchronization Therapy Is Associated With Reduced RHO-Kinase Activation

• Main Authors: Maria Paz Ocaranza (Author), Jorge E. Jalil (Author), Rodrigo Altamirano (Author), Ana de León (Author), Jackeline Moya (Author), Alejandra Lonis (Author), Luigi Gabrielli (Author), Paul Mac Nab (Author), Samuel Córdova (Author), Alejandro Paredes (Author), Ismael Vergara (Author), Alex Bittner (Author), Karime Sabat (Author), Karla Pastorini (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Reverse remodeling is a clinically relevant endpoint in heart failure with reduced ejection fraction (HFrEF). Rho-kinase (ROCK) signaling cascade activation correlates with cardiac remodeling and left ventricular (LV) systolic dysfunction in HFrEF patients. Cardiac resynchronization ther...