Alphataxin, an Orally Available Small Molecule, Decreases LDL Levels in Mice as a Surrogate for the LDL-Lowering Activity of Alpha-1 Antitrypsin in Humans

• Main Authors: Cynthia L. Bristow (Author), Ronald Winston (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The abundant blood protein α1-proteinase inhibitor (α1PI, Αlpha-1, α1-antitrypsin, SerpinA1) is known to bind to the active site of granule-associated human leukocyte elastase (HLE-G). Less well known is that binding of α1PI to cell surface HLE (HLE-CS) induces lymphocyte locomotion mediated by memb...