Targeted siRNA Delivery and mRNA Knockdown Mediated by Bispecific Digoxigenin-binding Antibodies

• Main Authors: Britta Schneider (Author), Michael Grote (Author), Matthias John (Author), Alexander Haas (Author), Birgit Bramlage (Author), Ludger M lckenstein (Author), Kerstin Jahn-Hofmann (Author), Frieder Bauss (Author), Weijun Cheng (Author), Rebecca Croasdale (Author), Karin Daub (Author), Simone Dill (Author), Eike Hoffmann (Author), Wilma Lau (Author), Helmut Burtscher (Author), James L Ludtke (Author), Silke Metz (Author), Olaf Mundigl (Author), Zane C Neal (Author), Werner Scheuer (Author), Jan Stracke (Author), Hans Herweijer (Author), Ulrjch Brinkmann (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bispecific antibodies (bsAbs) that bind to cell surface antigens and to digoxigenin (Dig) were used for targeted small interfering RNA (siRNA) delivery. They are derivatives of immunoglobulins G (IgGs) that bind tumor antigens, such as Her2, IGF1-R, CD22, and LeY, with stabilized Dig-binding variabl...