Automated approach for the evaluation of glutathione-S-transferase P1-1 inhibition by organometallic anticancer compounds

• Main Authors: Sarah A. P. Pereira (Author), A. Catarina Baptista L (Author), Lorenzo Biancalana (Author), Fabio Marchetti (Author), Paul J. Dyson (Author), M. Lúcia M. F. S. Saraiva (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel automated method based on sequential injection analysis (SIA), a non-segmented flow injection technique, was developed to evaluate glutathione S-transferase P1-1 (GST P1-1) activity in the presence of organometallic complexes with putative anticancer activity. The assay is based on the react...