Obeticholic Acid Induces Hepatoxicity Via FXR in the NAFLD Mice

• Main Authors: Chuangzhen Lin (Author), Bingqing Yu (Author), Lixin Chen (Author), Zhaohui Zhang (Author), Weixiang Ye (Author), Hui Zhong (Author), Wenke Bai (Author), Yuping Yang (Author), Biao Nie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Obeticholic acid (OCA), a potent farnesoid X receptor (FXR) agonist, is a promising drug for nonalcoholic fatty liver disease (NAFLD); however, it can cause liver injury, especially at high doses. Here, we investigated the role of FXR in the high-dose OCA-induced hepatoxicity in the condi...