Changes in Methylation Patterns of Tumor Suppressor Genes during Extended Human Embryonic Stem Cell Cultures

• Main Authors: Kyung Min Kang (Author), Jeoung Eun Lee (Author), Ji Eun Park (Author), Hyunjin Kim (Author), Hee Yeon Jang (Author), Minyeon Go (Author), Dong Ryul Lee (Author), Sung Han Shim (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

While studies on embryonic stem cells have been actively conducted, little is known about the epigenetic mechanisms in human embryonic stem cells (hESCs) in extended culture systems. Here, we investigated whether CpG island (CGI) methylation patterns of 24 tumor suppressor genes could be maintained...