Correlation of Receptor Occupancy of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Mouse Brain With In vivo Activity of Allosteric mGluR1 Antagonists

• Main Authors: Gentaroh Suzuki (Author), Hiroko Kawagoe-Takaki (Author), Takao Inoue (Author), Toshifumi Kimura (Author), Hirohiko Hikichi (Author), Takashi Murai (Author), Akio Satow (Author), Mikiko Hata (Author), Shunsuke Maehara (Author), Satoru Ito (Author), Hiroshi Kawamoto (Author), Satoshi Ozaki (Author), Hisashi Ohta (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: The aim of this study was to clarify the relationship between receptor occupancy and In vivo pharmacological activity of mGluR1 antagonists. The tritiated mGluR1-selective allosteric antagonist [3H]FTIDC (4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6...