Calmodulin mutations affecting Gly114 impair binding to the NaV1.5 IQ-domain

Calmodulin mutations affecting Gly114 impair binding to the NaV1.5 IQ-domain

Missense variants in CALM genes encoding the Ca2+-binding protein calmodulin (CaM) cause severe cardiac arrhythmias. The disease mechanisms have been attributed to dysregulation of RyR2, for Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) and/or CaV1.2, for Long-QT Syndrome (LQTS). Rece...

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Main Authors: Malene Brohus (Author), Ana-Octavia Busuioc (Author), Reinhard Wimmer (Author), Mette Nyegaard (Author), Michael Toft Overgaard (Author)
Format: Book
Published: Frontiers Media S.A., 2023-08-01T00:00:00Z.
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3rd Floor Main Library

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