Mechanochemical Synthesis and Physicochemical Characterization of Previously Unreported Praziquantel Solvates with 2-Pyrrolidone and Acetic Acid

• Glavni autori: Debora Zanolla (Autor), Lara Gigli (Autor), Dritan Hasa (Autor), Michele R. Chierotti (Autor), Mihails Arhangelskis (Autor), Nicola Demitri (Autor), William Jones (Autor), Dario Voinovich (Autor), Beatrice Perissutti (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2021-10-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Two new solvates of the widely used anthelminthic Praziquantel (PZQ) were obtained through mechanochemical screening with different liquid additives. Specifically, 2-pyrrolidone and acetic acid gave solvates with 1:1 stoichiometry (PZQ-AA and PZQ-2P, respectively). A wide-ranging characterization of...