Mechanochemical Synthesis and Physicochemical Characterization of Previously Unreported Praziquantel Solvates with 2-Pyrrolidone and Acetic Acid

• Auteurs principaux: Debora Zanolla (Auteur), Lara Gigli (Auteur), Dritan Hasa (Auteur), Michele R. Chierotti (Auteur), Mihails Arhangelskis (Auteur), Nicola Demitri (Auteur), William Jones (Auteur), Dario Voinovich (Auteur), Beatrice Perissutti (Auteur)
• Format: Livre
• Publié: MDPI AG, 2021-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Two new solvates of the widely used anthelminthic Praziquantel (PZQ) were obtained through mechanochemical screening with different liquid additives. Specifically, 2-pyrrolidone and acetic acid gave solvates with 1:1 stoichiometry (PZQ-AA and PZQ-2P, respectively). A wide-ranging characterization of...