Mechanochemical Synthesis and Physicochemical Characterization of Previously Unreported Praziquantel Solvates with 2-Pyrrolidone and Acetic Acid

• Main Authors: Debora Zanolla (Author), Lara Gigli (Author), Dritan Hasa (Author), Michele R. Chierotti (Author), Mihails Arhangelskis (Author), Nicola Demitri (Author), William Jones (Author), Dario Voinovich (Author), Beatrice Perissutti (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Two new solvates of the widely used anthelminthic Praziquantel (PZQ) were obtained through mechanochemical screening with different liquid additives. Specifically, 2-pyrrolidone and acetic acid gave solvates with 1:1 stoichiometry (PZQ-AA and PZQ-2P, respectively). A wide-ranging characterization of...