Santalol Isomers Inhibit Transthyretin Amyloidogenesis and Associated Pathologies in Caenorhabditis elegans

• Main Authors: Amirthalingam Mohankumar (Author), Duraisamy Kalaiselvi (Author), Govindhan Thiruppathi (Author), Sivaramakrishnan Muthusaravanan (Author), Subramaniam Vijayakumar (Author), Rahul Suresh (Author), Shinkichi Tawata (Author), Palanisamy Sundararaj (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transthyretin (TTR) is a homotetrameric protein found in human serum and is implicated in fatal inherited amyloidoses. Destabilization of native TTR confirmation resulting from mutation, environmental changes, and aging causes polymerization and amyloid fibril formation. Although several small molec...