Triptolide in the treatment of systemic lupus erythematosus - regulatory effects on miR-146a in B cell TLR7 signaling pathway in mice

• Main Authors: Yi Zhang (Author), FengQi Zhang (Author), YiNi Gao (Author), MeiJiao Wang (Author), Yan Gao (Author), HaiChang Li (Author), Jing Sun (Author), ChengPing Wen (Author), ZhiJun Xie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: To clarify the mechanism of triptolide (TP) in alleviating the conditions underlying SLE.Methods: Eight-week-old MRL/lpr mice were randomly divided into a model group (n = 5), low-dose TP (TP-L) group (n = 5), and high-dose TP (TP-H) group (n = 5). Mice in these groups were gavaged with n...