Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure

• Main Authors: Marina R. Carpinelli (Author), Michael E. de Vries (Author), Alana Auden (Author), Tariq Butt (Author), Zihao Deng (Author), Darren D. Partridge (Author), Lee B. Miles (Author), Smitha R. Georgy (Author), Jody J. Haigh (Author), Charbel Darido (Author), Simone Brabletz (Author), Thomas Brabletz (Author), Marc P. Stemmler (Author), Sebastian Dworkin (Author), Stephen M. Jane (Author)
• Format: Book
• Published: The Company of Biologists, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cleft lip and palate are common birth defects resulting from failure of the facial processes to fuse during development. The mammalian grainyhead-like (Grhl1-3) genes play key roles in a number of tissue fusion processes including neurulation, epidermal wound healing and eyelid fusion. One family me...