Continuous NPWT Regulates Fibrosis in Murine Diabetic Wound Healing

• Main Authors: Mengfan Wu (Author), Dany Y. Matar (Author), Zhen Yu (Author), Ziyu Chen (Author), Samuel Knoedler (Author), Brian Ng (Author), Oliver A. Darwish (Author), Sadaf Sohrabi (Author), Leigh Friedman (Author), Valentin Haug (Author), George F. Murphy (Author), Yuval Rinkevich (Author), Dennis P. Orgill (Author), Adriana C. Panayi (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Scarring is associated with significant morbidity. The mechanical signaling factor yes-associated protein (YAP) has been linked to Engrailed-1 (En1)-lineage positive fibroblasts (EPFs), a pro-scarring fibroblast lineage, establishing a connection between mechanotransduction and fibrosis. In this stu...