A structural biology approach to understand human lymphatic filarial infection.

• Main Authors: Raghavendra Sashi Krishna Nagampalli (Author), Krishnasamy Gunasekaran (Author), Rangarajan Badri Narayanan (Author), Angela Peters (Author), Rajagopalan Bhaskaran (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The presence of aspartic protease inhibitor in filarial parasite Brugia malayi (Bm-Aspin) makes it interesting to study because of the fact that the filarial parasite never encounters the host digestive system. Here, the aspartic protease inhibition kinetics of Bm-Aspin and its NMR structural charac...