CD3 aptamers promote expansion and persistence of tumor-reactive T cells for adoptive T cell therapy in cancer

• Main Authors: Ashwathi Puravankara Menon (Author), Helena Villanueva (Author), Daniel Meraviglia-Crivelli (Author), Hisse M. van Santen (Author), Joschka Hellmeier (Author), Angelina Zheleva (Author), Francesca Nonateli (Author), Timo Peters (Author), Tassilo L.A. Wachsmann (Author), Mercedes Hernandez-Rueda (Author), Johannes B. Huppa (Author), Gerhard J. Schütz (Author), Eva Sevcsik (Author), Beatriz Moreno (Author), Fernando Pastor (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The CD3/T cell receptor (TCR) complex is responsible for antigen-specific pathogen recognition by T cells, and initiates the signaling cascade necessary for activation of effector functions. CD3 agonistic antibodies are commonly used to expand T lymphocytes in a wide range of clinical applications,...