A reduced form of nicotinamide riboside defines a new path for NAD+ biosynthesis and acts as an orally bioavailable NAD+ precursor

• Main Authors: Judith Giroud-Gerbetant (Author), Magali Joffraud (Author), Maria Pilar Giner (Author), Angelique Cercillieux (Author), Simona Bartova (Author), Mikhail V. Makarov (Author), Rubén Zapata-Pérez (Author), José L. Sánchez-García (Author), Riekelt H. Houtkooper (Author), Marie E. Migaud (Author), Sofia Moco (Author), Carles Canto (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: A decay in intracellular NAD+ levels is one of the hallmarks of physiological decline in normal tissue functions. Accordingly, dietary supplementation with NAD+ precursors can prevent, alleviate, or even reverse multiple metabolic complications and age-related disorders in diverse model o...